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Too big and cannabis can clump and clog the opening

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In September 2018, FDA announced the issuance of more than 1,300 warning letters and civil money penalty complaints to retailers who illegally sold JUUL and other e-cigarette products to minors

Acknowledgements This study was supported in part by NIDA grants: 1R56DA036556, R01DA029845, R01DA030394, R01HL102119, and R21DA032022, Natural Science Foundation of Zhejiang Province Grant LZ15H180001, the program for professor of special appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and the Hangzhou Qianjiang Endowed Professor Program and the Youth 1000 Talent Program of China