Chronic stress, environmental toxins, diets low in nutrients but high in inflammatory triggers, sleep deprivation, smoking, sugar, excess alcohol, and other stressors slowly deplete glutathione levels
Kratochwil C, Flechsig P, Lindner T, Abderrahim L, Altmann A, Mier W, et al
Studies show that immune checkpoint blockade therapy activates CD8+ T cells to secrete IFN-, promoting ACSL4 growth, regulating cellular acyl-chain phospholipid-fatty acid binding to arachidonic acid (AA), and inducing tumor cell ferroptosis (110)
The proposed mechanism is indirect modulation of the NO pathway rather than direct receptor agonism, though the precise molecular binding event has not been definitively characterized in peer-reviewed work