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Massachusetts led the way when it became the first state in November 2019 to prohibit the sale of all flavored tobacco products, including menthol cigarettes and e-cigarettes

Similarities between the two have been pointed out, such as the mysterious, enigmatic nature they share, the references to smoking present in Half-Life: Alyx , and spoken lines themselves, G-Man's infamous line "Prepare for unforeseen consequences" bearing a slight resemblance to the Smoking Man's line "There have been unforeseen events"

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Additionally, more studies are necessary to determine the contribution of frequent and uncommon flavoring ingredients in e-liquids to the regulation of immune checkpoints, since these can modulate immune response in different disease contexts