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In addition, it can lead to a decrease in serum levels of IL-1 and rheumatoid factor (RF), an increase in serum levels of IL-6, IL-13, IL-15, IL-23, TNF-, and IFN-, and the activation of NK cells, which can often lead to autoimmune diseases and autoimmune complications of DPA treatment (see Figure 3) [9,170,190,191,192]

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