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Moreover, surgical treatment involves deep brain stimulation (DBS) and lesioning surgery, out of which the former could be effective for patients of PD in the advanced stage who no longer respond adequately to the medicines

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The transport of macromolecules can also occur via adsorptive-mediated transcytosis (AMT) [ Figure 3 (E) ] which is based on the electrostatic interactions resulting from the interaction between negatively-charged domains on the cellular membrane and positively-charged transporters