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After validation, the structures of the HaloTag adducts were deposited in the PDB database under PDB codes 7ZBA (MeTRaQ-G), 7ZBB (TRaQ-G-ctrl) and 7ZBD (TRaQ-G)

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In addition, excessive activation of beta-site APP cleaving enzyme 1 and glycogen synthase kinase 3 beta (GSK-3) can lead to increased production of A and hyper-phosphorylation of tau protein, respectively, thereby fostering their misfolding and aggregation [32, 72] (Fig

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10.5455/OVJ.2021.v11.i2.9 65

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