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Our research shows that tobacco companies delayed the withdrawal of fully branded packaging and stalled introducing plain packaging

It can even kill them, just like it can people

Furthermore, disruption of various cell signaling pathways by smoking-associated ROS, mostly mediated through the transcription factors NF-B and signal transducer and activator of transcription 3 (STAT3), hypoxia-inducible factor-1, kinases, growth factors, cytokines and other proteins, and enzymes, have been linked to cellular transformation, inflammation, proliferation, invasion, angiogenesis, and metastasis of cancer (reviewed in refs

In addition a number of general legal defences may also apply, depending on the circumstances of the case