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Scientific evidence published in peer-reviewed cardiology journals shows that nicotine increases heart rate, constricts blood vessels, and raises blood pressure, even in young people without underlying conditions

[428] [429] An Illinois State Historical Society marker in Benton, Illinois, commemorates Harrison's visit in the town in 1963 to see his sister, making him the first Beatle to visit the United States

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[29] Health advocates have been slow to support a harm reduction method out of concern that tobacco companies cannot be trusted to sell products that will lower the risks associated with tobacco use