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This includes patients who have problems related to the ileum which is the final section of the small intestine, such as Crohns disease

While GLP-1 receptor agonists primarily engage hypothalamic circuits, cagrilintide activates hindbrain satiety regions via AMYR and AMYR an anatomically and pharmacologically complementary mechanism that underpins the rationale for combination therapies. Important to Know: One of the most significant areas of cagrilintide investigation involves its use in multi-peptide pathway research, particularly in combination with GLP-1 receptor agonists

REDEFINE is a phase 3 clinical development program evaluating once-weekly subcutaneous CagriSema for obesity

PubMed Link Jalili M, et al