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Numerous studies have suggested that sphingolipid metabolites function as key regulators in the T-cell lineage specification and immune responses in inflammatory diseases (5861, 63), including MS and EAE (56, 57, 62, 64)

[6] After deep intramuscular injection the lipophilic ester diffuses slowly from the oil depot, undergoes enzymatic cleavage to free testosterone and enters the systemic circulation, where roughly 98 % is reversibly bound to sex-hormone-binding globulin and albumin while the unbound fraction translocates across cell membranes to activate androgen receptors

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