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What Happens When Recycling Slows Down In patients, the enzyme GR, which is responsible for recycling spent/oxidised glutathione back to fully loaded, slows down, which leads to the accumulation of oxidised glutathione (GSSG) and the depletion and inability to produce GSH

The mice were euthanized through CO2 inhalation when the tumor volume surpassed 1500 mm or when the mice showed signs of serious weight loss, dreadful weakness, or Unhealed ulcers, indicating they were moribund

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