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Immunosenescence, a process of immune system dysregulation, causes the elderly to produce low-affinity immunoglobulins at an increased rate, leading to elevated serum levels of IgG1 and IgG4 (124)

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Pregnant women are at increased risk of iron deficiency because iron requirements are significantly increased during pregnancy due to increased iron utilization by the developing fetus and placenta and because of blood volume expansion (69)

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