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She didn't have any trouble scaling back -- she smoked more out of boredom and habit than nicotine addiction, she says -- but she has found her social smoking at bars surprisingly hard to kick

In contrast, the Cys349 to Tyr substitution alters the subcellular localization of ToMV replication proteins, such that replication proteins of L 11 tend to be membrane-bound, which causes a shortage of replication proteins in the soluble fraction

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However, its effectiveness for smoking cessation is controversial, given the range of smoking outcomes reported by research- some smokers quit smoking by switching to EC, some become dual users, and remaining smokers quit tobacco and discontinue EC use [2, 15]