Nutrients 9 , 1211 (2017)
VacA insertion facilitates mitochondrial depolarization, swelling, and the release of pro-apoptotic factors such as apoptosis-inducing factor (AIF) and cytochrome c ( Listeria monocytogenes , an intracellular pathogen, secretes listeriolysin O (LLO), a cholesterol-dependent cytolysin that destabilizes host membranes, including mitochondrial membranes (Li et al., 2021)
Secondary outcomes included treatment discontinuation rates (defined as premature withdrawal from the trial for any reason before study completion in either the curcumin or placebo groups) and incidence of adverse events (characterized as any unfavorable medical occurrences attributable to trial participation)
391 Furthermore, mTOR, particularly mTORC1, is crucial for regulating cellular metabolism and growth by detecting and combining different nutritional and environmental signals