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Vitamin B12 traditionally has been administered parenterally for chronic enteropathies and EPI
Standard esophageal HRM can be supplemented with adjunctive tests such as the multiple rapid swallow sequence, during which a patient is instructed to swallow water every 2 seconds for 5 swallows to assess inhibitory input and peristaltic reserve, and a rapid drink challenge to assess functional obstruction at the esophagogastric junction (EGJ)
Others are synthesized by the body and are therefore "non-essential", like Vitamin D for example