Despite their clinical heterogeneity, these conditions share core pathological mechanisms including oxidative stress, chronic inflammation, hormonal imbalance, metabolic dysfunction, extracellular matrix remodeling, and dysregulated cell survival
Given that the PVN is a crucial brain region for sensing stress 51,52 , these findings could also explain that acute stress and chronic negative mood disorders cause disturbances in intestinal functions 53 , such as diarrhea and constipation 54,55
PubMed Central, Lahner, Edith, et al
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