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The second dose is offered six to 24 months after the first dose

As a caveat to the proposed structure and content of the VAM and va deletion mutations presented here, we acknowledge that they were generated under the assumption that the events leading to creation of VAM and va resulted in clean deletions, whereby a large contiguous chromosomal region of chromosome 21 was removed

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McGrady added there were an estimated 108,000 fewer smokers over that period as a consequence of the changes to packaging and labeling.