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10.2147/IJN.S213883 53 JelovacN.SikiricP.RucmanR.PetekM.MarovicA.PerovicD.et al (1999)

Over time, chronic inflammation can quietly affect nearly every system in the body contributing to fatigue, brain fog, hormone imbalance, weight gain, digestive issues, joint pain, accelerated aging, poor recovery, and increased risk for cardiovascular disease, autoimmune disorders, insulin resistance, and neurodegenerative disease

Peptides loaded onto MHC class I are recognized by a specific TCR of CD8+ T cells, which are activated to exert their cytotoxic activity against tumor cells presenting the same peptide-MHC-I complex