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"Conversely, if dopamine function normalizes with abstinence this rather indicates that alterations were induced by substance consumption." One limitation of the study is its small size, which makes it difficult to draw statistically meaningful conclusions, the authors note

In addition, a study revealed that OSMI-1-mediated inhibition of O -GlcNAcylation induces ferritinophagy and mitophagy to jointly promote free ferrous iron release to induce ferroptosis, and inhibiting mitophagy by knocking down PINK1 partially prevented de-O-GlcNAcylation-induced ferroptosis [72]