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Clinical cross-sectional studies demonstrated that urinary excretion of proximal tubular enzymes (beta-hexaminidase, N -acetyl-beta-d-glucosaminidase, neutral endopeptidase), and free filtered beta-2 microglobulin and retinol binding protein was higher in smoking individuals than in their nonsmoking counterparts [24,25,26,27]

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(The researchers also studied Philadelphia, and found that only 2 percent of cigarettes there come from out of state.) Once the trafficked cigarettes have arrived in their new states, officials say, theyre often sold through local stores with a wink and a nod