One important source of LIP expansion is the selective autophagic degradation of ferritin, which leads to the accumulation of iron in the cytoplasm in the form of Fe 2+
The apparent K m values of AsGGT1 and AsGGT2 for -glutamyl- S -allyl-L-cysteine determined in this study (86 M and 1.1 mM, respectively) are lower than or comparable to those of partially purified onion GGT for -glutamyl- S -propenyl-L-cysteine ( K m = 1.68 mM) and for -glutamyl- S -methyl-L-cysteine ( K m = 0.55 mM
These analyses indicated that when the top 100 altered metabolites were compared the LC group was segregated from both the R and HC groups ( Supplementary Figures 2A, B , Supplementary Table 2 )
Therefore, for true tyrosinase inhibitors, four types of the mechanism were postulated and demonstrated, such as non-competitive, competitive, uncompetitive, and mixed type (competitive/uncompetitive) inihibtion 17,28,35