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There is substantial evidence that the expression of SOCS3 protein increases with aging in several cells/tissues, such as rat myocardium [162], hypothalamus [163], and human blood mononuclear cells [164] as well as human sarcopenic skeletal muscles [165] and the brains of Alzheimers patients [166]

Another casecontrol study revealed that AD patients had significantly lower lutein concentrations of red blood cells than control subjects and higher peroxidized phospholipid concentrations [28]