Y.JensenA
15 Bissett DL, Robinson LR, Raleigh PS, Miyamoto K, Hakozaki T, Li J, Kelm G R
In the synovial fluid of individuals with OA, increased lactate facilitates lactylation of UDP-glucose dehydrogenase (UGDH) at lysine 6, disrupting its interaction with signal transducer and activator of transcription 1 (STAT1), suppressing its enzymatic activity and glycosaminoglycan synthesis, and altering its nuclear-cytoplasmic distribution, activating the MAPK signaling pathway and ultimately contributing to OA progression
Scientific interest in multi-compound metabolic formulations continues to expand as researchers examine the interconnected relationships between mitochondrial communication, energy metabolism, NAD-associated pathways, and intracellular regulatory mechanisms