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Description

The side chains of F34 and P33 interact with the bottom of the phenyl ring

While the majority of EC cases are low-grade, early-stage endometrioid EC with favorable prognosis, approximately 1020% fall into the high-risk category, characterized by grade 3 endometrioid tumors (G3EEC), serous ECs (SEC), clear-cell ECs (CCEC), and dedifferentiated carcinosarcomas, all of which exhibit significantly poorer outcomes [3, 4]