doi: 10.1016/j.bbrc.2004.01.082 25 YuanJLuYWangHFengYJiangSGaoXHet al
In cultured human placental cytotrophoblasts and explants from normotensive and preeclamptic pregnancies, luteolin was identified as a potent inhibitor of sFlt-1 release, reducing secretion by more than 95% compared to vehicle controls ( 4.7 Gynecologic malignancies Gynecologic cancers, including ovarian, cervical, and endometrial cancers, account for around 20% of global female cancer burden ( + /ALDH + stem-like ovarian cancer cells, luteolin decreased sphere formation and downregulated stemness genes (SOX2, OCT4, NANOG)
No severe headaches were reported, and no participant discontinued due to this symptom
Across studies, this multi-pathway profile has been explored in the context of skin structure, recovery, and regenerative processes