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& Navarro, M

If risk factors exist, professional assessment helps decide whether testing is appropriate

Procyanidin oligomers and polymers reach the large intestine where they are subjected to microbial metabolism yielding e.g., phenylvalerolactones (see section 6.1 Pre-systemic metabolism: role of gut microbiota)

Among the three precursor amino acids, cysteine proves to be the rate-limiting factor for GSH synthesis since its intracellular availability is lower than the Km value of -glutamyl cysteine synthase (GCS), whereas glutamate and glycine are abundant in the cell [7, 70]