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Tissue and Cell Type Considerations Research across different tissue models has revealed some cell-type-specific differences in how IGF-1 DES and IGF-1 LR3 behave: Smooth muscle cells: IGF-1 DES has been studied in smooth muscle cell migration and proliferation models

In particular, effects such as increased gut microbiota richness and diversity and decreased Firmicutes/Bacteroidetes ratio have been reported, demonstrating the potential of ITCs for obesity prevention

Part of this response in 3MH excretion may have reflected a decrease in gut protein breakdown because IGF-I, and especially the IGF analogs increased the gut weight by up to 45%