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doi: 10.7759/cureus.26243

That's well below toxic thresholds, but chronic administration over 6+ months hasn't been studied in controlled human trials

Consistently, Bap1 and Plxnb2 are involved in the regulation of stem cell fate and Chuk , Plxnb2 , Zfp750 and Crebbp promote keratinocyte differentiation 68,69,70,71