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In four randomized controlled trials (RCT) conducted in patients with obesity without T2D 15,16,17,18 , liraglutide 3.0 mg was compared to placebo as an adjunct to lifestyle optimization over 56 weeks, with the exception of the 3-year extension of the SCALE Obesity and Prediabetes study

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Impaired magnesium ion binding and carbohydrate kinase activities corresponded with dysfunctional RBKS and PRTFDC1, indicating TCA cycle disruption and mitochondrial oxidative phosphorylation inefficiency [63, 64]

Including foods high in vitamin B12 also has athlete-specific performance benefits