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Some researchers follow 2-months-on, 1-month-off cycling patterns to prevent potential receptor downregulation

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Nguyen M, Marcellus RC, Roulston A, Watson M, Serfass L, Murthy Madiraju SR, Goulet D, Viallet J, Belec L et al (2007) Small molecule obatoclax (GX15070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis