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In a key study by Masumoto and colleagues, 5 weeks of exercise in mice changed their gut microbiome and increased levels of butyrate (Matsumoto et al., 2008)

Additionally, the TRPM8 gene, which responds to cold stimuli, has been linked to an increased risk of chronic migraine in individuals carrying the TRPM8 rs10166942 T allele (Ling et al., 2019)

While correlation does not equal causation, the parallel decline of a regenerative peptide and the onset of hair thinning is biologically plausible and suggests that topical GHK-Cu supplementation could compensate for what the body no longer produces in sufficient quantities

But Im not sure you would say its secondary to some of the other ones that weve discussed because theres obviously some overlap here with healing and tissue repair