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Opioid Receptors: While not a classic opioid, DSIP exhibits agonistic activity on opioid receptors or modulates endogenous opioid peptides (enkephalins/endorphins)

Keywords: Retatrutide, Triple agonist, Glucagon, Obesity, Type 2 diabetes, GLP-1 Introduction Obesity is a chronic progressive disease that increases the risk of multiple obesity-related complications such as cancer and cardiovascular disease and is associated with impaired quality of life, and reduced life expectancy [1]

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