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doi: 10.1038/s44259-023-00007-2 226 LeiJ.et al

2.14 IPA analysis Significantly differentially expressed genes, and corresponding Log 2 Fold Change values were imported to IPA bioinformatics software (Qiagen, Redwood City, CA, USA, Winter Release 2021)

The mechanisms behind this sleep improvement likely involve ergothioneines effects on mitochondrial function, oxidative stress reduction, and cellular energy metabolism

Research demonstrates that TB-500 forms functional complexes with PINCH-1 and integrin-linked kinase (ILK) that can inhibit TNF--induced NF-B activation through blocking RelA/p65 translocation, providing rapid suppression of inflammatory transcriptional programs