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For example, BDNF and its analogues GSB-106 and GSB-214 can upregulate the PI3K/Akt and ERK pathways to promote endogenous neurogenesis after brain injury and improve neurological function ( Conclusion Currently, HIBD remains the leading cause of neonatal death and long-term neurological dysfunction

The evidence comes from heterogeneous study designs with differing methods and inclusion criteria, and more favorable results were seen mainly in animal models

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In patients who cannot tolerate the 25-mg oral formulation or T2DM patients who require additional weight reduction, a transition to injectable semaglutide 1.7 mg once weekly may be considered, followed by dose escalation as tolerated