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Annals of Internal Medicine

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Preparations of 5-Aminosalicylate (5-ASA) for Treatment of Ulcerative Colitis Generic name Mesalamine Proprietary name Rowasa Canasa Pentasa Asacol Delzicol Apriso Lialda Olsalazine Sulfasalazine Balsalazide Dipentum Azulfidine Colazal Giazo Daily dose, ga Formulation Sites of delivery Active Maintenance Enema suspension Suppository Ethylcellulose-coated granules (controlled-release) Eudragit-Scoated tablets (dissolves at pH 7.0) Eudragit-Scoated tablets (dissolves at pH 7.0) Enteric coating (dissolves at pH 6) around polymer matrix Enteric coating (dissolves at pH 7) around polymer matrix with lipophilic and hydrophilic matrices 5-ASA dimer linked by azo bond 5-ASA linked to sulfapyridine by azo bond 5-ASA linked to inert carrier by azo bond 5-ASA linked to inert carrier by azo bond From rectum to splenic flexure Rectum Duodenum, jejunum, ileum, colon Terminal ileum, colon Terminal ileum, colon Terminal ileum, colon 4 1 2-4 2.4-4.8 2.4-4.8 1.5 4b 1b 1.5-4 1.6-4.8 1.6-4.8 1.5 Terminal ileum, colon 2.4-4.8 2.4 Colon Colon Colon Colon 2-3 2-4 6.75 6.6 1 2-4 4.5-6.75 4.4-6.6 a Dose ranges reflect those commonly used in clinical practice and are broader than those specifically studied in clinical trials

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