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Compounded medications are not subject to FDA approval and lack the same safety and efficacy data as FDA-approved commercial medications

[149] Derived from Table 2 available on [150] History [edit] Between 1849 and 1887, Thomas Addison described a case of pernicious anemia, William Osler and William Gardner first described a case of neuropathy, Hayem described large red cells in the peripheral blood in this condition, which he called "giant blood corpuscles" (now called macrocytes), Paul Ehrlich identified megaloblasts in the bone marrow, and Ludwig Lichtheim described a case of myelopathy

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Some clinicians prefer to use a methylmalonic acid (MMA) test in place of a homocysteine test, but MMA is also a non-specific biomarker