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These parameters may be evaluated using tumor biopsy specimens and patient-derived samples through a combination of complementary experimental and clinical methodologies, including immunohistochemistry or spatial proteomics to assess FSP1 expression and localization, metabolomics or lipidomics-based omics approaches to quantify CoQ redox state and lipid peroxidation signatures and functional ferroptosis-sensitivity assays in patient-derived tumor models such as organoids or xenografts

NAD(+) augmentation restores mitophagy and limits accelerated aging in Werner syndrome

Signal 22 (1), 166

[DOI] [PubMed] [Google Scholar] 109.Yang H., Chen S., Yin S., Ding Q