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It leads to tolerance, meaning higher doses are needed for the same effect
Abbreviations CASP: Critical Appraisal Skills Programme CI: Confidence Intervals HR: Hazard Ratios ICD: International Classification of Diseases NIH: National Institutes of Health OR: Odds Ratio PRISMA: Preferred Reporting for Systematic Review and Meta-analysis RR: Risk Ratios SLT: Smokeless tobacco References Hecht SS (2019) Smokeless tobacco and its constituents
Smoking cigarette included
Sci Adv 5:eaay9763 Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Dav V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lsche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodrguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR (2014) A unified nomenclature and amino acid numbering for human PTEN
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