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The CLOCK/BMAL1 heterodimer combines with the E-box response element which located in the promoter region to stimulate the expression of other target genes, the core of which is the transcriptional expression of other clock genes, such as Periods ( PER1 , PER2 , and PER3 ), and Cryptochromes ( CRY1 and CRY2 )

Our focus in this article is to shed light on riboflavin neuroprotective characteristics, encouraging more research to be done in the future in this regard