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Mechanism 1: Mitochondrial Oxidative Stress EGCG at high concentrations generates reactive oxygen species (ROS) inside hepatocytes, a mechanism documented in multiple cell-culture and rodent studies [7]

Injection site rotation: Move sites week to week (abdomen, thighs, upper arms), keeping each shot at least 1 inch from the last to limit irritation and prevent lipohypertrophy [15]