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MHRA updates guidance for GLP-1 prescribers and patients

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The consistency of positive outcomes across diverse animal studies suggests real therapeutic potential, while the lack of large-scale human trials means optimal protocols remain somewhat empirical

This review focuses on six commonly abused drugs (Table 1), classified based on their pharmacological and neurotoxic profiles: Psychostimulants: Methamphetamine (METH), cocaine and synthetic cathinones (bath salts) primarily act on monoaminergic systems, leading to disruptions in dopamine, serotonin, and norepinephrine signaling (Sulzer et al., 1995