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It reduces the production of melanin, the pigment responsible for skin colour, leading to lighter skin

The mild OS may activate the bladder afferent nerves (188) and stimulate the detrusor muscle cells directly (195), leading to bladder hyperactivity, while severe or prolonged OS can induce detrimental alterations in nerves and the detrusor muscle ultimately resulting in detrusor underactivity (196)

6), consistent with a decrease in the hydrolysis of RanGTP and a reduction in RanGAP activity

Another effect, as postulated by Gaskill et al ., is an increase of dopamine in the CNS that may impact the functions of monocytes, macrophages, and T cells, including an increase of HIV-1 infection [14]