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These cells exit the bloodstream and invade different tissueslungs, liver, bone, and even the brainto give birth to new, often more aggressive tumors

DNA content was measured by sorting the fluorescence activated cells by flow cytometry (LSRFortessa TM

FIGURE 3 To further confirm the hypothesis of a regulation of CBS activity by the Akt/GSK3 and/or NF-B pathways, we assessed the impact of inhibitors of these pathway (9-methylstreptimidone, 8-hydroxy verrucarin A, chrysomycin and daunorubicin) on the mRNA levels of CBS , CSE and NAD(P)H quinone oxidoreductase 1 ( NQO1 ), three genes known to be regulated by these pathways (Wang et al., 2014

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