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The treatment with the test micronutrients significantly reduced the mean fasting blood Hcy from 11.91 to 8.12 Mol/L ( p = 0.003), whereas Hcy did not change in the control group (from 11.38 to 12.11 Mol/L, n.s.) with a significant difference between subjects over time ( p 30% average reduction) and to the fact that 7 out of 8 treated patients having a high Hcy at baseline recorded a value within the normal limit after treatment
In turn, we speculated that this impairment of mitochondrial metabolism in FoB might explain the increase in aerobic glycolysis for ATP production
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Patients with insulin resistance or DM should be advised on dietary control, regular exercise and coronary risk factors modification (such as smoking cessation and lipid control)
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