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In some embodiments, the formulations described herein have a pH and/or practical osmolarity as described herein, and have a concentration of active pharmaceutical ingredient from about 0.0001% to about 60%, from about 0.001% to about 40%, from about 0.01% to about 20%, from about 0.01% to about 10%, from about 0.01% to about 7.5%, from about 0.01% to about 6%, from about 0.01 to about 5%, from about 0.1 to about 10%, or from about 0.1 to about 6% of the active ingredient by weight of the formulation

Ayoub E, Lehotzky D, Li L, Muftuoglu M, Nishida Y, Mohanty V, Leighton JS, Patsilevas T, Basyal M, Bedoy A, Haftarah T, Takahashi K, Chen K, Navin N, Issa GC, Getz G, Andreeff M

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It establishes that DSIP can cross into CSF but it also identifies plasma half-life as one of the three determinants of how much gets in