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According to the Centers for Disease Control and Prevention (CDC), early signs such as vomiting and fatigue develop within hours, while severe cases progress to jaundice, confusion, and multi-organ failure if untreated

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Although the search retrieved multicenter clinical trials that included LAC centers (166, 167), these were not incorporated as they did not focus on the region or present disaggregated results for their LAC population

Recent Phase IIb RewinD-LB trial findings support further study, and a global Phase III trial is scheduled to begin in the second half of 2026