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The strong interactions between METTYRTRP, observed through partial correlation networks at baseline confirms the connection between folate-mediated methionine formation, leading to methyl donation reactions that form the monoamine neurotransmitters serotonin, dopamine, and epinephrine 81,82

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Recycling of a drug in this way can extend the duration of the pharmacologic activity of a drug, leading to a more prolonged therapeutic effect and potentially a longer half-life of the drug