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This will depend on: Your age Whether or not you have heart disease, diabetes, or other blood vessel problems Whether you smoke or are overweight Whether you have high blood pressure or diabetes You are more likely to need medicine to lower your cholesterol: If you have heart disease or diabetes If you are at high risk for heart disease (even if you do not yet have any heart problems) If your LDL cholesterol is 190 mg/dL (4.92 mmol/L) or higher Almost everyone else may get health benefits from LDL cholesterol that is lower than 160 to 190 mg/dL (4.14 mmol/L to 4.92 mmol/L)