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The lowered proliferation was associated with the decrease in TNFalpha and IL-6 plasma concentrations, reduced hepatic HGF expression and delayed and/or altered activation of STAT3, JNK and ERK1/2 signaling pathways
Andreeva A, Kulesha E, Gough J, Murzin AG
[PubMed: 20814850] (Description of plans to evaluate the safety and efficacy of kava [Kalm project] in controlled trials with careful assessment of adverse events and mechanism of action using a well characterized kava product)
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