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It can result from elevated estrogen production (excess adipose aromatase activity), reduced estrogen clearance (impaired hepatic Phase I or Phase II metabolism), low SHBG (leaving more biologically active free estrogen), xenoestrogen exposure, or progesterone insufficiency

J Biol Chem 286(11):91969204 Kiriakov A, Khlebarova M, Staneva-Stoicheva D, Panova I (1973) The effect of prolonged treatment hypertensive rats with antihypertensive agents with different mechanisms of action on blood pressure and noradrenaline concentration in the myocardium, brain and aorta

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That is why we utilize medical-grade glass vials and specialized stoppers to maintain an inert environment